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The 2001 S-10 2WD is a 2- or 3-door, up to 4-passenger compact pickup, available in 6 trims, ranging from the Regular Cab Short Box to the LS Extended Cab. The 2001 S-10 2WD's closest competitors include the Ford Ranger Super Cab 2.3L 4x2, the GMC Sonoma 2WD, and the Toyota Tacoma 4X2.
Upon introduction, both trims are equipped with a standard 2.2-liter, I4, 120-horsepower engine that achieves 22-mpg in the city and 28-mpg on the highway. A 5-speed manual transmission with overdrive is standard, and a 4-speed automatic transmission with overdrive is optional.