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The 2001 S-10 4WD is a 3- or 4-door, up to 5-passenger compact pickup, available in 3 trims, ranging from the Extended Cab to the LS Crew Cab. The 2001 S-10 4WD's closest competitors include the Ford Ranger Regular Cab 3.0L 4x4, the GMC Sonoma 4WD, and the Nissan Frontier 4X4.
Upon introduction, both trims are equipped with a standard 4.3-liter, V6, 190-horsepower engine that achieves 15-mpg in the city and 18-mpg on the highway. A 5-speed manual transmission with overdrive is standard on the Extended Cab, and a 4-speed automatic transmission with overdrive is optional. A 4-speed automatic transmission with overdrive is standard on the LS Crew Cab.