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The 2000 Silverado 2500 Regular Cab is a 2-door, up to 3-passenger full size pickup, available in 6 trims, ranging from the 2WD Heavy Duty Long Box to the 4WD LS Long Box. The 2000 Silverado 2500 Regular Cab's closest competitors include the Dodge Ram Regular Cab 4X2, the GMC Classic Sierra 2500, and the GMC Sierra 2500 Regular Cab.
Upon introduction, both trims are equipped with a standard 6.0-liter, V8, 300-horsepower engine. A 5-speed manual transmission with overdrive is standard, and a 4-speed automatic transmission with overdrive is optional.