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The 2001 F-250 SD Regular Cab is a 2-door, up to 3-passenger full size pickup, available in 4 trims, ranging from the XL 4X2 to the XLT 4X4. The 2001 F-250 SD Regular Cab's closest competitors include the Chevrolet Silverado 2500, the Dodge Ram Regular Cab 4X2, and the GMC Sierra 2500 HD Regular Cab.
Upon introduction, both trims are equipped with a standard 5.4-liter, V8, 260-horsepower engine. A 5-speed manual transmission with overdrive is standard, and a 4-speed automatic transmission with overdrive is optional.