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The 2006 Sierra 3500 Crew Cab 4WD is a 4-door, up to 6-passenger full size pickup, available in 10 trims, ranging from the Work Truck Long Box SRW to the SLT Long Box DRW. The 2006 Sierra 3500 Crew Cab 4WD's closest competitors include the Chevrolet Silverado 2500HD Crew Cab 4WD, the Dodge Ram 3500 Quad Cab 4X4, and the Ford F-350 SD SuperCab 4X4.
Upon introduction, both trims are equipped with a standard 6.0-liter, V8, 300-horsepower engine. A 4-speed automatic transmission with overdrive is standard.
The 2006 Sierra 3500 Crew Cab 4WD is a carryover from 2005.