Pittsburgh Steelers at Cleveland Browns: Predictions, picks and odds for NFL Week 3 matchup

Coming off Week 2 losses, Kevin Stefanski's Cleveland Browns and Mike Tomlin's Pittsburgh Steelers face off in a pivotal AFC North matchup for Thursday Night Football.

Can Mitch Trubisky, Najee Harris and the Steelers' offense rebound and outpace a Browns' offense led by quarterback Jacoby Brissett? Will a Pittsburgh defense missing star linebacker T.J. Watt bounce back? First place in the division is on the line when these teams battle in Cleveland. Kickoff is set for 8:15 p.m. ET.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Steelers vs. Browns Week 3 game:

Steelers at Browns odds, moneyline and over/under

• Spread: Browns (-3.5)

• Moneyline: Browns (-210); Steelers (+175)

• Over/under: 38.5

• More odds, injury info for Steelers vs. Browns

 MYLES MYSTERY: Browns' Garrett not practicing, status for Steelers unknown 

POWER RANKINGS: Bills, Chiefs remain 1-2, but Dolphins among two new teams in top five

COACHING GRADES: Head of the class for Andy Reid, huge fail for Frank Reich

NFL Week 3 odds, predictions and picks

Steelers vs. Browns | Saints vs. Panthers | Texans vs. Bears | Chiefs vs. Colts | Bills vs. Dolphins | Lions vs. Vikings | Ravens vs. Patriots | Bengals vs. Jets | Raiders vs. Titans | Eagles vs. Commanders | Jaguars vs. Chargers | Rams vs. Cardinals | Falcons vs. Seahawks | Packers vs. Buccaneers | 49ers vs. Broncos | Cowboys vs. Giants

Lorenzo Reyes: Browns 24, Steelers 23

Historically, Mike Tomlin’s teams have performed well when playing as underdogs and when coming off a loss. The Browns, meanwhile, showed a lack of urgency late in their collapse against the Jets. I’m riding Cleveland on the moneyline because I think the Steeler defense isn’t the same without T.J. Watt, but I do like Pittsburgh to cover here.